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How does headspace gas chromatography work?

Time:2018/09/12   Pageviews:0    Share:
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Headspace Gas Chromatography/ Mass Spectrometry

A specific Gas Chromatography/Mass Spectrometry technique used to identify and/or quantify volatile organic compounds (VOC’s) present in the injected headspace sample.

About Headspace Gas Chromatography/Mass Spectrometry

Headspace GC/MS is a specific GC/MS technique used to analyze volatile compounds. A sample is placed in a closed sampling vessel, heated using a known temperature profile, and the vapor in the vessel is sampled for analysis.

Approaches
Solid or liquid samples are sealed in headspace vials.  Water or a high-boiling organic solvent may be added to the vial to dissolve the sample and facilitate release of volatile compounds to the gas phase. 

The headspace vials are typically heated to drive partitioning of volatiles from the solid or liquid phase into the gas phase.  Sample vials can be agitated during heating.

Sampling of the headspace for GC/MS injection  is usually performed via a heated gas-tight syringe.  If greater sensitivity is required, solid phase micro-extraction (SPME) can be used to concentrate volatiles prior to GC/MS analysis.

Sample Considerations

Virtually any sample that can be made to fit into a headspace vials can be tested.  However, the sample matrix itself should not be highly volatile.

The required sample size for headspace GC/MS is inversely proportional to the concentration(s) of volatile compound(s) that must be detected or quantified.

A sample size of 0.1 to 10 g is typical for headspace GC/MS vials.  Quantitative analysis usually requires a larger sample amount because a standard addition method is used.

Samples for quantitative headspace GC/MS vials should be homogeneous with respect to the concentration of volatiles.

Contact us to talk through your specific sample considerations and chromatography vials testing needs.

Experience

Work we've done:

Identification and quantification of residual solvents in packaging materials for food contact or pharmaceutical applications

Odor analysis in polyolefin packaging film

Identification and quantification of volatile organic compounds (VOC’s) present in polymers used for medical implants

Identification of compounds responsible for off-odor in post-consumer recycled carpet

Residual solvents in pharmaceutical actives and excipients

Quantification of residual blowing agents in polyolefin foam

Identification of off-gas products from combustion or pyrolysis of polymers

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